Scientists
has found out that Gold nanotubes can be used in fighting Cancer; internal
nanoprobes for high-resolution imaging; drug delivery vehicles; and agents for
destroying cancer cells.
The
article published in the journal, Advanced Functional Materials, details the
first successful demonstration of the biomedical use of gold nanotubes in a
mouse model of human cancer.
Dr Sunjie Ye, who is based in both the School of Physics and
Astronomy and the Leeds Institute for Biomedical and Clinical Sciences at the
University of Leeds, said: “High
recurrence rates of tumours after surgical removal remain a formidable
challenge in cancer therapy. Chemo- or radiotherapy is often given following
surgery to prevent this, but these treatments cause serious side effects.
Gold nanotubes – that is, gold nanoparticles with tubular
structures that resemble tiny drinking straws – have the potential to enhance
the efficacy of these conventional treatments by integrating diagnosis and
therapy in one single system.”
The study’s corresponding author Professor Steve Evans, from
the School of Physics and Astronomy at the University of Leeds, said: “Human
tissue is transparent for certain frequencies of light – in the red/infrared
region. This is why parts of your hand appear red when a torch is shone through
it.
“When the gold nanotubes travel through the body, if light
of the right frequency is shone on them they absorb the light. This light
energy is converted to heat, rather like the warmth generated by the Sun on
skin. Using a pulsed laser beam, we were able to rapidly raise the temperature
in the vicinity of the nanotubes so that it was high enough to destroy cancer
cells.”
In order to see the gold nanotubes in the body, the
researchers used a new type of imaging technique called ‘multispectral
optoacoustic tomography’ (MSOT) to detect the gold nanotubes in mice, in which
gold nanotubes had been injected intravenously. It is the first biomedical
application of gold nanotubes within a living organism. It was also shown that
gold nanotubes were excreted from the body and therefore are unlikely to cause
problems in terms of toxicity, an important consideration when developing
nanoparticles for clinical use.
“The nanotubes can be tumour-targeted and have a central
‘hollow’ core that can be loaded with a therapeutic payload. This combination
of targeting and localised release of a therapeutic agent could, in this age of
personalised medicine, be used to identify and treat cancer with minimal
toxicity to patients.” . Source: http://www.leeds.ac.uk/news/article/3662/gold_nanotubes_launch_a_three-pronged_attack_on_cancer_cells
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